What Source Of Protein Allergens Causes Laboratory Animal Allergies?

UQ Health Surveillance and Management of Laboratory Fauna Allergy and Asthma

Author: Occupational Health & Safe Sectionalization, University of Queensland

Regular exposure to small laboratory animals (rodents, insects and birds) in the workplace tin can cause development of allergic symptoms in some individuals, some studies guess between 11-44% of those working with small-scale lab animals will report work related allergic symptoms. The most common symptoms reported, involve irritation of the olfactory organ, eyes and skin. These symptoms occur as a result of becoming allergic to something (unremarkably an animal protein) in the workplace. Reducing workplace exposure to the allergen is the most of import attribute of preventing an allergy developing. Approximately 10% of individuals with allergic symptoms will develop asthma. This type of asthma is referred to equally 'occupational asthma'.

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Laboratory animals and respiratory allergies: The prevalence of allergies among laboratory brute workers and the demand for prophylaxis

Author: Ferraz, Erika et al.

Subjects exposed to laboratory animals are at a heightened risk of developing respiratory and allergic diseases. These diseases tin be prevented by unproblematic measures such equally the use of personal protective equipment. We report here the master findings of the Laboratory Animals and Respiratory Allergies Written report regarding the prevalence of allergic diseases among laboratory animal workers, the routine use of preventive measures in laboratories and animal facilities, and the need for prevention programs.

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The Science and Pervasiveness of Laboratory Brute Allergy

Author: Thomas 50. Wolfle and Robert K. Bush

Allergic reactions to animals are amidst the most common conditions that adversely affect the health of workers involved in the intendance and utilise of animals in inquiry (NRC 1997). Of the ninety,000 laboratory animal workers in the United States (Bland et al. 1987), up to 46% develop allergy to laboratory animals. Of those who develop symptoms, more than than 10% eventually develop occupationrelated asthma with symptoms that persist even after exposure ceases. A rare but life-threatening outcome of laboratory creature allergy (LAA1) is an anaphylactic reaction to animal bites, scratches, and needle sticks conveying the creature proteins. The manifestations of animal allergy, which range from rhinitis and itchy eyes to respiratory distress, have acquired more than one tertiary of laboratory animal workers at the National Institutes of Health to lose time from work (Bland et al. 1986).

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Machinery and Epidemiology of Laboratory Creature Allergy

Author: Robert K. Bush

Laboratory animal allergy (LAA) is a form of occupational allergic illness. The development of LAA is due to the presence of immunoglobulin E antibodies directed against animal proteins. The procedure of sensitization (development of immunoglobulin Due east antibodies) is a complex process that involves interaction of antigen-presenting cells and lymphocytes of the Thursday-two cell type. These cells generate a host of cytokines and other factors that lead to immediate hypersensitivity reactions and the generation of allergic inflammation. Typical symptoms of LAA include nasal symptoms (eastward.g., sneezing, watery discharge, and congestion) and skin rashes. Asthma, which produces symptoms of coughing, wheezing, and shortness of jiff, may bear upon xx to 38% of workers who are sensitized to laboratory animal allergens. Rarely, a generalized, life-threatening allergic reaction (anaphylaxis) may occur. The estimated prevalence of LAA is variable, depending on the method used for diagnosis, but even so may affect exposed workers. The presence of pre-existing allergies to nonworkplace allergens (e.m., dust mite, pollens, molds), exposure to laboratory animal allergens, and perhaps tobacco smoking are take a chance factors for the development of LAA. Progress in the agreement of the mechanism and epidemiology of LAA volition pb to improved methods for its prevention.

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Laboratory Animal Allergens

Author: Robert A. Wood

Allergic sensitivity to laboratory animals can pose a significant occupational hazard to anyone with regular animal contact. Reactions to mice and rats are well-nigh common, although all furred animals produce allergens that can lead to sensitization and disease. Most of the relevant allergens of laboratory animals have been defined and characterized, which has revealed that these allergens are typically modest, acidic glycoproteins and that many of them are members of a superfamily of extracellular proteins called lipocalins. In addition to agreement their molecular characteristics, the identification of these allergens has likewise made it possible to measure out their distribution in laboratory environments and to relate exposure levels to sensitization and symptoms. These studies accept shown that the major laboratory fauna allergens are carried on modest particles that are both capable of remaining airborne for extended periods and penetrating into the lower airways of exposed workers. These advances in the understanding of these important occupational allergens will allow for the development of better methods of diagnosis and avoidance for affected workers and others who may be at risk for future difficulties.

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Controlling Exposure to Laboratory Animal Allergens

Writer: D. J. Harrison

Laboratory animal allergy (LAA) is a pregnant occupational illness that may affect up to 1 third of personnel exposed to laboratory animals. Research has characterized the relative risks of exposure in terms of intensity, frequency, and duration associated with given tasks and piece of work areas in the animal facility. Studies have shown that reduced exposure to fauna allergens tin can reduce the incidence of LAA and salvage symptoms amidst affected workers. A combination of measures to eliminate or control allergen exposure, including technology and administrative controls and personal protective equipment, have been integral components of effective LAA management programs. This commodity provides a comprehensive review of exposure control options, considerations, and "best practices" relative to laboratory animal allergen in the context of traditional industrial hygiene methods.

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Laboratory Creature Allergy: A British Perspective on a Global Problem

Writer: Susan Gordon

In the Great britain, laboratory animal allergy (LAA) has been recognized as an important occupational disease for nearly 25 yr. However, introduction of health and safety legislation (east.yard., the Command of Substances Hazardous to Wellness Regulations of 1988) and an increasing knowledge of the factors that contribute to the etiology of this disease take had surprisingly little bear on on the prevalence and incidence of LAA over the last 10 to 20 yr. Studies of the relation between exposure to animal allergens and the development of LAA reveal that the gamble of illness increases with increasing intensity of exposure. Current prove suggests that fauna allergens are very stiff, and substantial decreases in allergen exposure are therefore necessary before a reduction in symptoms will exist observed. In the United Kingdom, it is unlikely that an Occupational Exposure Limit will be set for animal allergens in the almost hereafter, partly because an fairly standardized assay for quantifying exposure is not however available. Prevention of LAA in the future volition probably be driven past the needs of the manufacture and will almost likely rely on the adoption of guidelines describing "best practise," which incorporate sophisticated applied science methods of controlling exposure to creature allergens.

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Medical Surveillance of Allergy in Laboratory Animal Handlers

Author: James P. Seward

Alergic affliction is a serious occupational wellness concern for individuals who take contact with laboratory animals. Primary respiratory symptoms include allergic rhinitis, conjunctivitis, and asthma. Urticaria ("hives") is the almost common pare manifestation. The overall prevalence of allergic disease among laboratory animal handlers is almost 23%, and respiratory allergy is much more common than skin allergy. Prevention of animal allergy depends on control of allergenic material in the work surround. Personal protective equipment such as air filtering respirators should be used in improver to the other exposure command technologies where atmospheric condition require. Preplacement evaluation and periodic medical surveillance of workers are of import aspects of the overall occupational health program. The emphasis of these medical evaluations should be on counseling and early on disease detection. The article provides recommendations for the content of the medical evaluations.

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Assessment and Treatment of Laboratory Animal Allergy

Author: Robert K. Bush

Laboratory animal allergy (LAA) is a form of occupational sensitivity affecting up to one third or more of exposed workers. Symptoms involve the optics, olfactory organ, skin, and lower respiratory tract. Asthma may develop in xx to xxx% of sensitized individuals. An occupational medical history is the primary tool if a diagnosis of LAA is suspected. The diagnosis is confirmed by demonstrating the presence of immunoglobulin E antibodies to laboratory animal allergens by skin testing or in vitro assays. If laboratory animal allergen-induced asthma is suspected, measurements of lung function are necessary for confirmation and assessing the degree of impairment. Ane arroyo to the problem is presented in this article. For individuals with LAA, abstention of exposure is the principal treatment. For individuals who go along to work in the environment, pharmacological treatment of their symptoms may be necessary. Methods to prevent the development of LAA are also discussed.

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Source: http://escolifesciences.co.id/resources/163/

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